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KMID : 0358319950360010028
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Korean Journal of Urology
1995 Volume.36 No. 1 p.28 ~ p.37
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DNA Flow Cytometry in the Characterization of Transitional Cell Carcinoma of the Bladder: A Relation with Tumor Stage, Histopathologic Grade, Recurrence and Survival
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Abstract
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DNA flow cytometry was performed on 93 deparaffinized surgical specimens to investigate the relationship with tumor stage and histopathologic grade as well documented predicotrs of clinical recurrence and survival. Aneup0loidy, histopathologic
grade and
tumor stage were nonindependent variables, and all correlated to statistical significance with disease recurrence. The incidence of aneuploidy in the total specimens was 55 of 93 (59%). The incidence of recurrence rate in patients with diploid
tumor was
3/38 (7.9%) compared to 37/55(67%) in patients with aneuploid tumor (p=0.0000). The incidence of recurrence in patients with localized muslce invasion (T2, T3a) exhibiting concomittant diploidy was 4.3% compared to 43.5% in patients with
localized
muslce invasion and aneuploidy (p=0.0057). The incidence of recurrence in patients with grade II ( intermediate grade) exhibiting concomittant diploidy was 4.3% compared to 53.3% in those with grade II and aneuploidy (p=0.0057). The 5 years
acturarial
survival rate was 97% in patients with diploid tumors compared to 38% in patients with aneuploid tumors. The 5 years actuarial survival rate was 95% in patients with localized muscle invasion (T2, T3a) exhibiting concomittant diploidy compared to
39% in
those with aneuploid T2, T3a. the mean survival time was 91.4 months in patients with grade II exhibiting concomittant diploidy compared to 41.7 months in those with grade II exhibiting concomittant aneuploidy. In conclusion the identification of
DNA
aneuploid stemline in transitional cell carcinoma of the bladder is correlated statistically with a higher T stage as well as histopathologic grade. The markedly incerased probability of survival in patients with diploid tumor, even in localized
muscle
invasive group as well as intermediate histopathologic grade group suggests that DNA flow cytometry in transitional cell carcinoma of the bladder would significantly enhance prognostic stratification. transitional cell carcinoma of the bladder
would
significantly enhance prognsotic stratification.
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KEYWORD
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